Nalorphine hydrobromide

Infra-red Spectrum. Principal peaks at wavenumbers 1505,1121, 1155,1304, 805,945 (nalorphine hydrobromide, KBr disk). 

Dose. 5 to 10 mg of nalorphine hydrobromide intravenously, repeated if necessary. 

Nalorphine Hydrobromide 406.4 Codeine Phosphate Prazosin Hydrochloride... 

Sample preparation 10 mL Urine -I- 500 pL 100 p,g/mL nalorphine hydrobromide in MeOH -I- 1 mL concentrated HCl, heat at 100° for 1 h, cool, add 500 p-L saturated ammonium sulfate solution, adjust pH to 9 with 25% NaOH, dilute to 20 mL with water, add mixture to an Extrelut 20 column, let stand for 10 min, elute with 40 mL dichloromethane isopropanol 85 15. Add the eluate to 3 mL 200 mM HCl, extract, repeat extraction. Combine the aqueous phases and add them to 500 p.L saturated ammonium sulfate solution, adjust pH to 9.2 with 25% NaOH, dilute to 20 mL with water, add to another Extrelut 20 column, let stand for 10 min, elute with 40 mL dichloromethane isopropanol 85 15. Evaporate the eluate to dryness under a stream of nitrogen at 40°, reconstitute the residue in 100 p-L mobile phase, iiyect a 20 p-L aliquot. 

Injection of Nalorphine Hydrobromide, B,P Usually contains 10 mg in 1 ml of water for injection. 

The assay is the same as for nalorphine hydrobromide above using an amount of injection equivalent to about 0 2 g. 

G. Summerhays, Overdosage with nalorphine hydrobromide following self-inflicted injury with Immobilon, Vet. Rec., 1976, 99, 236. 

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