Nalorphine-6-glucuronide

Morphine-3-glucuronide (261) and the corresponding 3-sulfate had no MHP, sc, or ic activity, and morphine-3-phosphate and morphine-6-phosphate were similar to morphine in their responses. These activities were reflected in increased agonist potencies (MW, 3 x nalorphine) seen for nalorphine-6-glucuronide and -6-sulfate, with a maintenance of antagonist actions. 

Nalorphine and naloxone are also more effective parenterally than orally. Both are first-pass metabolized in the liver very rapidly, largely by glucuronide formation/420 421 The effects of these antagonists are almost immediate upon intravenous administration and last between 1 and 4h. Naltrexone, on the other hand, maintains a good level of oral activity and has a half-life of around 10 h/422 423 ... 

Simultaneous eunphetamine, benzphetamine, ben lmoiphine, bromo-STP, buprenor-phine, caffeine, codeine, codeine-N-oxide, dextromoramide, dextropropo Oqthene, diethyl-propion, dihydrocodeine, dihydromorphine, dimethylamphetamine, ephedrine, ethohep-tazine, ethylmorphine, etorphine, fenethyline, fenfluramine, fentanyl, hy ocodone, 4-hydro Q amphetamine, hydro ypethidine, levallorphan, levorphanol, mazindol, mephen-termine, mescaline, methadone, methamphetamine, methylenedioxyamphetamine, meth-ylephedrine, methylphenidate, morphine, morphine-3-glucuronide, morphine-N-oxide, nalorphine, naloxone, norcodeine, norlevorphanol, normetanephrine, normethadone, nor-morphine, norpethidine, norpipanone, noscapine, papaverine, pemoline, phenazocine, phendimetrazine, phenelzine, 2-phenethylamine, phenoperidine, phenylephrine, pholcod-eine, piritramide, prolintane, pseudoephedrine, STP, thebaine, tranylcypromine, trime-tho amphetamine, tyramine... 

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