Naftidrofuryl oxalate

Diperodon Hydrochloride 450.5 Anileridine Phosphate Naftidrofuryl Oxalate... 

The interactions of ergot derivatives with erythromycin and troleandomycin are well documented, well establish, and clinically important, whereas information about clarithromycin appears to be eonfined to three possible cases and that relating to oleandomycin to one case. There are no adverse reports about midecamycin, but it is expected to interact similarly. The concurrent use of all of these macrolides and ergot derivatives should be avoided. Some of the cases cited were effectively treated with sodium nitroprusside or naftidrofuryl oxalate, with or without heparin. "" " Spiramycin, and josamycin would not be expected to interact because they do not inhibit CYP3A4. However, there is one unexplained and unconfirmed report of an interaction with josamycin. "... 

Parenteral naftidrofuryl was withdrawn from the market following reports of severe adverse effects with intravenous or intra-arterial bolus injections, including intracardiac conduction defects, epileptic seizures, severe anaphylactic reactions, and acute renal insufficiency secondary to deposition of oxalate crystals in the tubules (SED-12, 473) (SEDA-17, 244). 

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