NADPH mitomycin

Komiyama, T., Kikuchi, T., and Sugiura, Y., 1986, Interactions of anticancer quinone dmgs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C, with NADPH-cytochrome P-450 reductase, xanthine oxidase and oxygen, J. Pharmacobiodyru 9 651-664. 

Mitomycin (mitomycin C, Mitocin-C, Mutamycin) is an antibiotic that is derived from a species of Streptomyces. It is sometimes classified as an alkylating agent because it can covalently bind to and cross-link DNA. Mitomycin is thought to inhibit DNA synthesis through its abihty to alkylate double-strand DNA and bring about interstrand cross-hnking. There is evidence that enzymatic reduction by a reduced nicotinamide-adenine dinucleotide phosphate (NADPH) dependent reductase is necessary to activate the drug. 

Pan, S., Andrews, P.A., Glover, C.J., and Bachur, N.R., 1984, Reductive activation of mitomycin C and mitomycin C metabolites catalysed by NADPH-cytochorome P-450 reductase and xantine oxidase. J. Biol. Chem. 259 959-962 Pollakis, G., Goormaghtigh, E., and Ruysschaert, J.-M., 1983, Role of quinone structure in the mitochondrial damage induced by antitumor anthracyclines. FEBS Lett. 155 267-272 Rappaport, S.M., McDonald, T.A., and Yeowell-O Connell, K., 1996, The use ofprotein adducts to investigate the disposition of reactive metabolites of benzene. Environ. Health Perspect. 104Suppl6 1235-1237... 

Basu S, Brown JE, Flannigan GM, et al. The immunohistochemical analysis of NAD(P)H quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumors relationship between tumor enzymology and clinical outcome following intravesical mitomycin C therapy. Int J Cancer 2004 109 703-709. 

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