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NAADP

NADP can be converted to nicotinic acid adenine dinucleotide phosphate (NAADP), which has distinct functions in the regulation of intracellular calcium stores. The studies of these new roles of NAD(P) in metabolism are in their early stages, but they might soon help to better understand and explain the symptoms of niacin deficiency ( pellagra) [1]. [Pg.851]

Brailoiu, E., Patel, S. and Dun, N. J. Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca2+ stores critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). Biochem. J. 373 313-318, 2003. [Pg.390]

LEMS Lambert-Eaton myasthenic syndrome NAADP nicotinic acid-adenine dinucleotide phosphate... [Pg.965]

Yusufi ANK, Cheng J, Thompson MA, Chini EN, Grande JP 2001 Nicotinic acid-adenine dinucleotide phosphate (NAADP) elicits specific microsomal Ca2+ release from mammalian cells. Biochem J 353 531—536... [Pg.41]

Kiselyov K, Mignery GA, Zhu MX, Muallem S 1999 The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol Cell 4 423-429 Lee HC 2000 NAADP An emerging calcium signaling molecule. J Membr Biol 173 1 -8 Lin S, Fagan KA, Li K-X, Shaul PW, Cooper DMF, Rodman DM 2000 Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry. J Biol Chem 275 17979-17985... [Pg.100]

Intracellular, ER-located, ligand-gated Ca2+ channels include the inositol-1,4,5-triphosphate (IP3) receptor, the ryanodine receptor (RyR), the NAADP receptor and the sphingolipid receptor [157-159]. The IP3 receptor Ca2+ channel is opened by IP3 generated as a result of G protein-(or RTK)-mediated PLC activation [159]. [Pg.535]

NAADP receptor Ca2+ channels are opened by very low NAADP concentrations but is blocked at higher NAADP concentrations [157]. Sphingolipid receptor Ca2+ channels may be opened by sphingosine-1-phosphate or sphingosyl-phosphorylcholine [157]. [Pg.536]

NAADP = Nicotinic Acid Adenine Dinucleotide Phosphate... [Pg.548]

Galione A., and Ruas M. 2005 NAADP receptors. Cell Calcium 38, 273-280. [Pg.477]

Chaki S, Muramatsu M, Otomo S (1994) Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine. Neurochem Int 24 37-41 Chameau P, Van d, V, Fossier P et al (2001) Ryanodine-, IP3- and NAADP-dependent calcium stores control acetylcholine release. Pflugers Arch 443 289-96 Chapman ER (2002) Synaptotagmin a Ca(2+) sensor that triggers exocytosis Nat Rev Mol Cell Biol 3 498-508... [Pg.245]

Lawrence DM, Major EO (2002) HIV-1 and the brain connections between HIV-l-associated dementia, neuropathology and neuroimmunology. Microbes Infect 4 301-8 Lee HC (2001) Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers. Annu Rev Pharmacol Toxicol 41 317—45... [Pg.404]

The second messengers cADPR (in which both N1 and N8 of adenine are ribosylated) and NAADP (in which the nicotinamide of oxidized nicotinamide adenine dinucleotide... [Pg.126]

NAADP-gated Ca2+ channel (NAADP receptor) (NAADP-R)... [Pg.153]

Nicotinic acid adenine dinucleotide 2 -phosphate (= NAADP)... [Pg.153]

Universal in animals likely universality in plants (NAADP-induced Ca2+ release)... [Pg.153]

NAADP, nicotinic acid adenine dinucleotide 2 -phosphate NAADP-R, nicotinic acid adenine dinucleotide 2 -phosphate receptor nACh-R, nicotinic acetylcholine receptor NADH DH, NADH dehydrogenase NADH/NAD"1", reduced/oxidized nicotinamide adenine dinucleotide NADH-U() OR, NADH-ubiquinone oxidoreductase... [Pg.844]

The nicotinamide nucleotide coenzymes function as electron carriers in a wide variety of redox reactions. In addition, NAD is the precursor of adenine dinucleotide phosphate (ADP)-ribose for ADP-ribosylation and poly(ADP-ribosylation) of proteins and cADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP). They act as second messengers and stimulate increases in intracellular calcium concentrations. [Pg.200]

Exchange of the nicotinamide moiety of NADP for nicotinic acid, forming NAADP. Early studies also showed that the enzyme can catalyze exchange of nicotinamide with a variety of other bases, including histamine. Formation of histamine adenine dinucleotide phosphate was thought to provide an alternative to amine oxidase for rapid inactivation of histamine. [Pg.219]

See other pages where NAADP is mentioned: [Pg.662]    [Pg.255]    [Pg.382]    [Pg.383]    [Pg.390]    [Pg.35]    [Pg.92]    [Pg.190]    [Pg.503]    [Pg.315]    [Pg.778]    [Pg.779]    [Pg.925]    [Pg.925]    [Pg.517]    [Pg.518]    [Pg.536]    [Pg.468]    [Pg.43]    [Pg.123]    [Pg.127]    [Pg.153]    [Pg.662]    [Pg.219]   
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See also in sourсe #XX -- [ Pg.315 , Pg.779 ]

See also in sourсe #XX -- [ Pg.4 , Pg.4 ]

See also in sourсe #XX -- [ Pg.60 ]

See also in sourсe #XX -- [ Pg.60 ]

See also in sourсe #XX -- [ Pg.315 , Pg.779 ]

See also in sourсe #XX -- [ Pg.60 ]

See also in sourсe #XX -- [ Pg.241 , Pg.244 ]

See also in sourсe #XX -- [ Pg.315 , Pg.779 ]

See also in sourсe #XX -- [ Pg.315 , Pg.779 ]



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Calcium, absorption regulation, cADP-ribose and NAADP

Insulin, pyruvate dehydrogenase secretion, cADP-ribose and NAADP

NAADP dinucleotide phosphate

Nicotinic acid adenine dinucleotide NAADP

Nicotinic acid adenine dinucleotide phosphate NAADP)

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