N-tert-BUTOXYCARBONYL-2-BROMOPYRROLE

Substituted Pyrroles from N-tert-Butoxycarbonyl-2-bromopyrrole ... [Pg.126]

N-tert Butoxycarbonyl-2-bromopyrrole 1H-Pyrrole-1-carboxylic add, 2-bromo-, 1,1-dimethylethyl ester (12) (117657-37-1)... [Pg.79]

SUBSTITUTtD PYRROLES FROM N-tert-BUTOXYCARBONYL-2-BROMOPYRROLE N-tert-BUTOXY-2-TRIMETHYLSILYLPYRROLE... [Pg.162]

A. N-tert-Butoxycarbonyl-2-bromopyrrole. A dry, 500-mL, three-necked, round-bottomed flask is equipped with a magnetic stirring bar, two solid addition funnels, and a three-way stopcock attached to a balloon filled with nitrogen. To the flask are added 4.5 g (67.2 mmol) of pyrrole (Note 1) and 180 mL of tetrahydrofuran (Note 2). The flask is evacuated and purged with nitrogen (Note 3). The stirred solution is cooled to -78°C with a dry ice-acetone bath (Note 4) and a catalytic amount (ca. 0.1 g) of azoisobutyronitrile (AIBN) (Note 5) is added via solid addition funnel. After 5 min, 9.57 g (33.6 mmol) of 1,3-dibromo-5,5-dimethylhydantoin (Note 6) is added over a 20-min period via solid addition funnel. The light-green mixture is stirred for an additional 10... [Pg.151]

Wha Chen, E. Kyle Stephenson, Michael P. Cava, and Yvette A. Jackson 151 2-SUBSTITUTED PYRROLES FROM N-tert-BUTOXYCARBONYL-2-BROMOPYRROLE N-tert-BUTOXY-2-TRIMETHYLSILYLPYRROLE... [Pg.317]

In the present procedure, pyrrole is brominated under mild conditions to the very labile 2-bromopyrrole using 1,3-dibromo-S.5-dimethylhydantoin the latter reagent gives better results than the previously employed N-bromosuccinimide. Direct conversion of 2-bromopyrrole to Its more stable N-tert-butoxycarbonyl derivative... [Pg.241]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...