N-methyl-/V-

NEP471 88EUP287951], N-Methylaniline was reacted with dimethyl 1-methoxyethylidenemalonate at 180°C for 1.5 hr to give dimethyl -(N-methyl-/V-phenylamino)ethylidenemalonate in 32% yield (69JA6683) (Scheme 20). 

The size of the. /V-alkyl group influences the affinity of the molecule for the enzyme [12] /V-propyIcaproamide has a Km value almost 27-fold higher than that of N- rn c th y I c ap ro am i de. However, comparison of the enzymatic Zj/2 values (which are proportional to the ratio Km/VmiI) revealed that N-methyl-, /V-ctliy 1-, and /V-propyIcaproamidc were hydrolyzed at almost the same rate. 

Fig. 9. Retention behavior of blood cells on poly(HEMA co[jV-methyl-/V-(4-vinylphenethyl) ethylenediamine (HAV) (pH 7.2, 23 °C flow rate, 0.4 ml/min flow time, 3,5 min). Open circles, lymphocytes closed squares, platelets open triangles, erythrocytes AVEMA, N-methyl- V-(4-vinyl-phenethyl)ethylenediamine [Ref. 115]...

Site of the N-methyl-v-aspartate Receptor - Binding Studies, Molecular Modeling and Structure-Activity-Relationships, Sci. Pharm. 68,3-14 (2000)... 

The S-(N -methyl-/V -phenylcarbamoyl)sulfenyl group (Snm group) produced under these conditions is stable to HF or CF3S03H. Since there are few acid-stable —SH protective groups, the Snm group should prove to be useful where strong acids are encountered in synthesis. 

Andersen, R.A. and T.R. Kemp Accumulation of 4-(N-methyl-V-nitrosamino)-l-(3-pyridyl)-l-butanone in alkaloid genotypes of burley tobacco during postharvest processing Comparisons with V -nitrosonomicotine and probable nitrosamine precursors Cancer Res. 45 (1985) 5287-5293. 

TMU tetramethylurea DMF dimethylformamide DMAA N.N.-dimethylacetamide MPF N-methyl-/V-2-pyridylfornnamide HMPA hexamethylphosphoramide. 

Diazomethane reacts rapidly with unesterified fatty acids in the presence of a little methanol, which catalyses the reaction, to form methyl esters. The reagent is generally prepared as a solution in diethyl ether by the action of alkali on a nitrosamide, e.g. N-methyl-/V-nitroso-p-toluene-sulfonamide (Diazald, Aldrich Chemical Co., Milwaukee, U.S.A.). Solutions of diazomethane are stable for short periods If stored refrigerated in the dark over potassium hydroxide pellets. If they are kept too long, polymeric byproducts form which may interfere with the subsequent GC analysis. 

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