N-Methyl-4-piperidyl

Preparation of 4-aza-S-(N-methyl-4-piperidyll-10,11-dihydro-SH-dibenzo[a,d]cycloheptene-S-ol Add 17.4 g of N-methyl-4-chloropiperidine to a stirred mixture containing 3.2 g of magnesium, 20 ml of anhydrous tetrahydrofuran, 1 ml of ethyl bromide and a crystal of iodine. Reflux for two hours, cool to 30°-35°C and add a solution of 13 g of 4-aza-10,11 -dihydro-5H-dibenzo[a,d] cycloheptene-5-one in 25 ml of tetrahydrofuran. Stir for five hours, remove the solvent by distillation in vacuo and add 250 ml of ether. Add 100 ml of 10% ammonium chloride solution and extract the mixture with chloroform. Concentrate the chloroform solution to a residue and recrystallize from isopropyl ether obtaining 20 g of the carbinol,... 

N-methyl-4-piperidvl benzi/ata and the methiodide An intimate mixture of 0.1 mol of N-methyM-piperidinol hydrochloride and 0.1 mol diphenylchloroacetyl chloride is heated at 160°C to 180°C until the evolution of hydrogen chloride ceases (usually about 4 to 5 hours). The melt is then dissolved in 500 ml of water and the resultant mixture heated on a steam bath for about Vi hour, after which time complete solution is effected. The acid solution is cooled and rendered alkaline with ammonium hydroxide solution whereupon the ester is precipitated.The ester is purified either by removal by filtration and recrystallization from benzene petroleum ether or by extracting the mixture with benzene and precipitating the ester by the addition of petroleum ether. After recrystallization there is obtained about 0.06 mol of N-methyl-4-piperidyl benzilate, melting point 1 62°C to 163°C. 

N-methyl-4-piperidyl benzilate methobromide To a suspension of 0.15 mol of freshly prepared silver bromide in 300 ml of anhydrous methanol is added a solution of 0.1 mol of quaternary iodide obtained as above. The mixture is stirred and refluxed for several hours after which time transhalogenation is complete. The mixture is cooled, the insoluble silver... 

N-Methyl-4-piperidyl cyclopentyl-phenylglycolate (Agent EA 3443) CAS 37803-21-0 RTECS —... 

The short acting, centrally active cholinolytic drug N-methyl-4-piperidyl cyclopentyl methylethynyl glycollate (PCMG) has been used to analyse the suppressing influence of cholinolytics on alternation behaviour. 

Preparation of4-aza-5-(N-methyl-4-piperidyl)-10,1 l-dihydro-BH-dibenzofa.d]cycioheptene-... 

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