N-linked oligosaccharide chains

Elbien, A.D. (1987) Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains. Annual Review of Biochemistry 56, 497-534. 

Besides the prominent mucin domains, gel-forming mucins have other domains (i.e., CS-, D-, C-, and CK-domains as shown in Fig. 2.1) (Perez-Vilar and Hill 1999 Dekker et al. 2002) characterized by being (a) under-glycosylated, although most have one or more N-linked oligosaccharide chains (see Section... 

Darbepoetin alfa is a second-generation ESA. It is a 165-amino-acid protein, with five N-linked oligosaccharide chains resulting from five amino acid substitutions in the erythropoietin peptide backbone. As a result of this, it has a longer half-life than erythropoietin, and so is given either once a week or in some patients, every two weeks. In addition, due to its longer duration of action, the intravenous and subcutaneous doses of darbepoetin alfa are the same. 

Amino-acid-glycosylated protein hormone which contains 5 N-linked oligosaccharide chains Aranesp (darbepoetin alfa) Anemia Amgen 5... 

Figure 2. Generalized N-linked oligosaccharide chain to which are attached peripheral-chain terminating sequences, for example those expressing the blood group and related antigens on single oi repeating lactosamine-type sequences, (continued)...

Figure 6. High-mannose and hybrid-type N-linked oligosaccharide chains.

The biosynthesis of the N-linked oligosaccharide chain is initiated by the assembly of the high mannose type of oligosaccharide on the ER membrane (Figure 2). This assembly process involves the participation of a carrier molecule called dolichyl-phosphate (Dol-P), which is a component of the ER membrane, and is a lipid structure... 

Fujiwara, S., Shinkai, H., Deutzmann, R., Paulsson, M. and Timpl, R. (1988) Structure and distribution of N-linked oligosaccharide chains on various domains of mouse tumour laminin. Biochem. J. 252 453-461. 

N-linked oligosaccharide chain. An N-glycosidic bond to the side-chain... 

Kijimoto, S., et al. (1985). Analysis of N-linked Oligosaccharide Chains of Glycoproteins on Nitrocellulose Sheets Using Lectin-peroxidase Reagents, Anal. Biochem. 147 222-229. 

Inoue, S., Tanaka, K., Tanaka, H., Ohtomo, K., Kanda, T., Imamura, M., Quan, G., Kojima, K., Yamashita, T., Nakajima, T., Taira, H., Tamura, T., Mizuno, S., 2004. Assembly of the silk fibroin elementary unit in endoplasmic reticulum and a role of L-chain for protection of alphal,2-mannose residues in N-linked oligosaccharide chains of fibrohexamerin/P25. European Journal of Biochemistry 271 (2), 356—366. 

The Invariable Core of N-linked Oligosaccharide Chains, and Site- and Protein-Specific Processing... 

Docherty, P.A. Kuranda, M.J. Aronson, N.N. Jr., BeMiller, J.N. Myers, R.W. Bohn, J.A. Effect of a-D-Mannopyranosylmethyl-p-Nitrophenyltriazene on Hepatic Degradation and Processing of the N-Linked Oligosaccharide Chains of a 1-Acid Glycoprotein. J. Biol Chem. 1986, 261, 3457-3463. 

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