N- formamide

Acidic hydrolysis of isonitriles proceeds in two steps to the N-formamide and subsequently to the amine derivatives in common with nitrilium ions produced in the Ritter reaction using hydrogen... 

Other examples of this class of compounds have been reported recently in studies aimed at isolating inhibitors of melanin biosynthesis [147, 148]. The amino, N-formamide, and N, N-dimethyl derivatives of homothallin II (128) have also been isolated from Trichoderma spp [138, 148]. 

Secondary amines do not give the expected N-TBDMS derivatives under the conditions normally used for similar alcohol protection (Chapter 14). Instead, N-formamides are produced (3) in good yield through a DMF-derived Vilsmeier intermediate. 

Zee-Cheng and Cheng s (73JHC85 73JHC867) route to the benzo[c]phe-nanthridines utilized the formation of the N-formamide derivatives 41-43 from the corresponding tetralone intermediates 2939,40 by addition of formamide and formic acid under Leuckart conditions. The derivatives... 

Pyridine-substituted nicotines, nornicotines, and anabasines are available from a-cyano-amines by a new synthesis. The syntheses of ( )-[l - N]nornicotine and ( )-[l - N]nicotine have been described, from cyclopropyl 3-pyridyl ketone and [ N]formamide. 4-Methylnicotine has been prepared it shows no nicotine-like pharmacological activity. " An investigation into the stereochemical factors involved in the behaviour of nicotine and related compounds in the Menschutkin reaction has been conducted.A bridged nicotine , 1,2,3,5,6,10b-hexahydropyrido[2,3-g]indolizine (44), has been synthesized by carboxylation of the dilithium derivative of 2-methylnornicotine followed by cyclisation and reduction with borane in tetrahydrofuran. Several 5-halogeno-nicotines have been prepared and their pK values and biological activities measured. ... 

CH3COCH3 acetonitrile, CH3C = N formamide, HCONH2 sulfur dioxide, SO2 ammonia, NH3 trimethylamine, N(CH3)3 ethylene glycol, HOCH2CH2OH. 

Based on the previous discovery that trichlorosUyl derivatives could be activated by N-formamide-based Lewis base organocatalysts. Sun et al. designed a series of novel catalysts (82 and 83) derived from L-pipecohnic acid, which features a six-membered ring frame rather than 72 and 73, which have a five-membered ring derived from L-proline [50]. Surprisingly, both 82 and 83 proved to be superior catalysts for the hydrosilation of N-aryl ketimines. Both enantioselectivities and... 

N-formamide-based Lewis bases 956 formyl cyclopropanes 507... 

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