N-Acetylglucosamine deacetylase

K Young, LL Silver, D Bramhill, P Cameron, SS Eveland, CR Raetz, SA Hyland, MS Anderson. The envA permeability/cell division gene of Escherichia coli encodes the second enzyme of lipid A biosynthesis. UDP-3-0-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase. J Biol Chem 270 30384-30391, 1995. 

Enzymatic hydrolysis is a useful method for the preparation of monomers from chitin and chitosan because the yield of monomers is greater by enzymatic hydrolysis than by acid hydrolysis. The enzyme chitin deacetylase hydrolyzes the acetamido group in the N-acetylglucosamine units of chitin and chitosan, thus generating glucosamine imits and acetic acid (Fig. 2.5). 

Weidanz, J.A. Campbell, R Moore, D. DeLucas, L.J. Roden, L. Thompson, J.N. Vezza, A.C. N-acetylglucosamine kinase and N-acetylglucosamine 6-phosphate deacetylase in normal human erythrocytes and Plasmodium falciparum. Br. J. Haematol., 95, 645-653 (1996)... 

Yamada-Okabe, T. Sakamori, Y. Mio, T. Yamada-Okabe, H. Identification and characterization of the genes for N-acetylglucosamine kinase and N-acetylglucosamine-phosphate deacetylase in the pathogenic fungus Candida albicans. Eur. J. Biochem., 268, 2498-2505 (2001)... 

Another method of deacetylation (enzymatic bioconversion) makes use of enzyme, chitin deacetylase foimd in several fungi and in some insect species [15-17]. It acts by catalyzing deacetylation of N-acetylglucosamine residues, resulting in conversion of chitin to chitosan. 

Yadav, V., Panilaitis, B., Shi, H., Numuta, K., Lee, K., Kaplan, D.L., 2011. N-acetylglucosamine 6-phosphate deacetylase (nagA) is required for N-acetyl glucosamine assimilation in Gluconacetobacter xylinus. PloS One 6 (6), el8099. 

Yamano, N. Higashida, N. En(k>, C. Sakata, N. Fujishima, S. Maruyama, A. Higashihara, T. (2000) Purification and charactaization of Y-acetylglucosamine-6-phosphate deacetylase from a psychrotrophic marine bacterium, Alteromonas species. Mar. Biotechnol., 2, 57-64. 

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