N-Acetyl-5-hydroxytryptamine

Klemm, P., Hecker, M., Stockhausen, H., Wu, C. C., Thiemermann, C., Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat, Br. 

N-Acetyltransferase uses acetyl-CoA to acetylate the amino moiety of arylal-kylamines. In mammalian pineal gland, this enzyme catalyzes the production of N-acetyl-5-hydroxytryptamine, which is the precursor of melatonin. It is also involved in the inactivation of monoaminergic neurotransmitters in insects. 

C12H14N202 N-acetyl-5-hydroxytryptamine 17994-17-1 25.00 1.1608 2 24097 C12H15N08 4-mtrophenyl-a-D-glucopyranoside 3767-28-0 25.00 1.3572 2... 

Substrates (p-octopamine, dopamine, or 5-hydroxytryptamine) were separated from their N-acetylated products on an Ultrasphere I.P. C18 column (4.6 mm x 250 mm, 5 pm). The mobile phase was comprised of 75 mAf monobasic sodium phosphate, 1 pAf EDTA, 0.35 mAf 1-octanesulfonate (sodium salt), 11% methanol, and 4% acetonitrile. Coulometric detection was used. Detection of p-octopamine and its N-acetylated product was achieved at a potential of +0.75 V, while dopamine, 5-hydroxytryptamine and their products were detected at +0.50 V. 

Leptodactylus pentadactylus and L. ocellatus native to South and Central America, contain considerable amounts of 5-hydroxytryptamine derivatives, like N-methylserotonine, bufotenin and bufotenidin as well as leptodactylin and candicin (ref. 4). Of a new type are substances like histamin, methyl-, and acetyl-histamins, and spinaceamin. Spinaceamin can be synthesized in vitro by a biomimetic reaction of histamin and formaldehyde in aqueous solution at pH 6.8, and room temperature (ref. 5). 

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