Myopathies fiber regeneration

Nervous system dysfunction beyond neuro-ophthafinolog-ical aspects is common in hypothyroidism. Electrophysiological abnormafities reported include sensorimotor axonal polyneuropathy, carpal tunnel syndrome and myopathy (Neeck et al.y 1990 Palumbo et ai, 2000 Duyff et ai, 2000). Sural nerve biopsies have previously showed reduction of myelinated fibers and degenerative changes in axons of all fiber classes with incomplete regeneration (Meier and Bischoff,... 

Ordinary myopathic aspects-, these include necrosis, phagocytosis, regeneration, and vacuolation of muscle fibers. Dysimmune "inflammatory" myopathies typically have accumulated lymphocytes and macrophages in relation to abnormal muscle fibers and/or around blood vessels. Sometimes deposition of immunoglobulins in blood vessels is a major pathogenic mechanism, as in dermatomyositis [37, 38]. 

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