Nervous system dysfunction

There is a similar high prevalence of peripheral neuropathy (34%) in the pediatric population infected with HIV (Araujo et al. 2000). The frequency of IDP in the HIV-infected population is unknown but is thought to be rare (Wulff et al. 2000). In an outpatient population of HIV positive patients, mononeuritis multiplex and lumbosacral polyradiculopathy were found in less than 1% of patients with AIDS (Fuller et al. 1993). HIV-associated autonomic nervous system dysfunction is also not uncommon as up to 66% of patients have papillary involvement and 15% have sympathetic and parasympathetic involvement causing orthostatic hypotension and respiratory sinus arrhythmia (Gluck et al. 2000). 

Orlandi G, Eanucchi S, Strata G, PataleoL, Landucci Pellegrini L, Prontera C, Martini A, Murri L. Transient autonomic nervous system dysfunction during hyperacute stroke. Acta Neurol Scand 2000 102(5) 317-321. 

Hereditary deficiency of phosphoglycerate kinase (PGK) is associated with hereditary hemolytic anemia and often with central nervous system dysfunction and/or myopathy. The first case, reported by Kraus et al. (K24), is a heterozygous female, and the results are not so clear. The second family, reported by Valentine et al. (V3), is a large Chinese family, whose pedigree study indicates that PGK deficiency is compatible with X-linked inheritance. To date, 22 families have been reported (04, T25, Y3). Nine of these have manifested both symptoms five have shown only hemolysis seven have shown the central nervous system dysfunction and/or myopathy but without hemolysis and one case, PGK Munchen, is without clinical symptoms (F5). PGK II is an electrophoretic variant found in New Guinea populations (Y2). Red blood cell enzyme activity, specific activity, and the kinetic properties of this polymorphic variant are normal. 

Rabbit 0.04 mg/kg BW After 16 weeks, central nervous system dysfunction 20... 

Araki, S, Murata, K, Aono, H. (1987). Central and peripheral nervous system dysfunction in workers exposed to lead, zinc and cooper. A follow-up study of visual and somatosensory evoked potentials. Int. Arch. Occup. Environ. Health, 59, 177-87. 

Damstra T. 1978. Environmental chemicals and nervous system dysfunction. Yale J Biol Med 51(4) 457-468. 

Diseases mediated through ion channel receptors include cardiovascular disease, hypertension, and central nervous system dysfunctions. A voltagegated ion channel is a key to the treatment of cystic fibrosis (see Exhibit 2.4). 

Hollander, E., Schiffman, E., Cohen, B., Rivera-Stein, M.A., Rosen, W., Gorman, J.M., Fyer, A.J., Papp, L., and Liebowitz, M.R. (1990) Signs of central nervous system dysfunction in obsessive-compulsive disorder. Arch Gen Psychiatry, 47 27-32. 

Menkes, D.L. (1999) Images in neurology. The cutaneous stigmata of Fabry disease an X-linked phakomatosis associated with central and peripheral nervous system dysfunction. Arch Neurol 56 487. 

Hollander E, Schiffman E, Cohen B, et al Signs of central nervous system dysfunction in obsessive-compulsive disorder. Arch Gen Psychiatry 47 27-32, 1990b Hollander E, Mullen L, DeCaria CM, et al Obsessive compulsive disorder, depression, and fluoxetine. J Clin Psychiatry 52 418-422, 1991 Hollander E, De Caiia CM, Nitescu A, et al Serotonergic function in OCD. Arch Gen Psychiatry 49 21-28, 1992... 

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