Myoglobin active-site structure

The active site structure of peroxidases (Fig. 16-13) is quite highly conserved. As in myoglobin, an imidazole group is the proximal heme ligand, but it is usually hydrogen bonded to an aspartate carboxylate as a catalytic diad (Fig. 16-13).223 In cytochrome c peroxidase... 

Figure 1 (a) Myoglobin active site (adapted from ref. 10) (b) molecular structure and atom labeling scheme... 

STRUCTURE OF THE ACTIVE SITE IN MYOGLOBIN AND HEMOGLOBIN COMPARISON TO MODEL COMPOUNDS... 

X-ray crystallographic structures of myoglobin and hemoglobin were first completed in 19662 and 19753, respectively. Since then, many other X-ray crystallographic studies of deoxy- and oxy- as well as met-myoglobin and hemoglobin have been carried out.22,24 Additionally, researchers have studied the carbon monoxide bound moieties MbCO and HbCO as well as MbNO. Site-directed mutagenesis of residues near the active sites of Mb and Hb have yielded... 

Following myoglobin and lysozyme, bovine carboxypeptidase A was the third protein to have its 3-D structure solved at high resolution. The active site zinc is bound to His69, Glu72 and Hisl96 (Figure 12.4), and to a water molecule, which is displaced when a... 

Structure of the Active Site in Myoglobin and Hemoglobin Comparison to Model Compounds... 

Figure 3.12 Schematic of the structure of the complex formed between 22 and myoglobin leading to cleavage of myoglobin at Gln(91)-Ser(92). The picture was obtained through optimization ofthe structure of the active site of 22 by molecular modeling programs with the structure of myoglobin frozen as that in the crystal.

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