Mycobacterium johnei Mycobactins

Snow GA (1965) The Structure of Mycobactin P, a Growth Factor for Mycobacterium johnei, and the Significance of its Iron Complex. Biochem J 94 160... 

These compounds, acting as growth factors for Mycobacterium johnei, have been isolated from other species of mycobacteria and named mycobactins (44). Components P (M. phlei) (122, 113, 125) and T (M. tuberculosis) (124, 126) have been characterized. The former has been shown to give stable, crystalline complexes with ferric iron while the latter is obtained directly from M. tuberculosis as the ferric derivative both probably exist in Nature as the ferric complexes. Although mycobactin preparations support the growth of Arthrobacter JG-9 (23, 105), neither ferrichrome nor hemin will serve this function in M. johnei and it hence seems that the Mycobacteria require their own, specific iron transfer factors (125). 

Francis. J., H. M. Macturk, S. Madinaveitia and G. A. Snow Mycobactin, a growth factor for Mycobacterium johnei, I. Isolation from Mycobacterium phlei. Biochem. J. 55, 596 (1953). 

Snow, G.A. Mycobactin. A growth factor for Mycobacterium johnei. Part II. Degradation and identification of fragments. J. Chem. Soc. 1954. 2588-2596. 

Francis et and Snow have isolated from Mycobacterium phlei and M. tuberculosis two series of growth factors for M. johnei, containing the mycobactins P (12) and T (13), respectively. 

Mycobactins, Growth factors for Mycobacterium para tuberculosis (M, johnei). the organism responsible for Johne s disease in cattle. Mycobactins are structurally complex niderophores (microbial iron chelators). At least nine mycobactins, designated with the letters A, R H, M. N, P R S, and T have been isolated from various non-pathogenic species of Mycobacterium. Earlier studies were actually on mycobactin P see isoln from M. phlei Francis et al. Nature 163, 365 (1949) eidem. Biochem. J. 55, 596 (1953) structure Snow ibid. 94, 160 (1965), Separation and identification of mycobactins White, Snow, ibid. 108, 593 (1968) 111, 785 (1969). Chemical and biological properties eidem. ibid. 

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