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Mutants gene knock-outs

Sherman et al. have analyzed the function of the MitM methyltransferase in more detail [113]. They knocked out the MitM gene and found that mitomytin C production was abolished, and were able to isolate a small quantity of 9a-demethyl mitomycin A (62) from this mutant (Figure 11.9). MitM was expected to act as an O-methyltransferase, but surprisingly recombinant MitM converted 62 into 9-epi-mitomydn B (63), hence acting as an aziridine N-methyltransferase. Mitomy-... [Pg.412]

The bakers yeast Saccharomyces cerevisiae represents probably the currently best researched and understood eukaryotic organism. Most of its genes have been knocked out for functional studies, and hence a vast variety of mutant strains as well as tools for their manipulation are available. This in concordance with short generation times and a growth medium that is comparable in cost and complexity to bacterial media has made the yeast system a frequent choice for the evaluation of transmembrane carriers. [Pg.591]

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Gene knock-outs

Genes mutant

Knock

Knock out

Knocking

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