Mutagenicity pentachlorophenol

Pentachlorophenol is a poison by several routes. Human exposure causes increased respiradon, fever, tachycardia, muscle weakness, and cardiac failure. Many toxic effects are due to impurides in commercial-grade material. A teratogen and mutagen. Pentachlorophenol and 2,4,6-trichlorophenol may interfere with mitochondrial oxidadve phosphor)Iadon. When heated to decomposidon they emit toxic fumes of CL. See also specific compounds, PHENOL, and CHLORIDES. 

Pentachlorophenol is not a carcinogen, and the evidence for mutagenicity is mixed. No carcinomas were produced in rodents, regardless of the composition of the PCP solution tested or route of exposure (USEPA 1980 Choudhury et al. 1986). Some studies suggested that PCP may be... 

Fahrig, R. Steinkamp-Zucht, A. (1996) Co-recombinogenic and anti-mutagenic effects of diethylhexylphthalate, inactiveness of pentachlorophenol in the spot test with mice. Mutat. Res., 354, 59-67... 

Nishimura. N. Oshima. H. (1983) Mutagenicity of pentachlorophenol, dinitro-o-cresol and their related compounds. Jpn. J. ind. Health, 25, 510-511... 

Bordelon NR, Donnelly KC, George SE. Pentachlorophenol potentiates benzo [a] pyrene DNA adduct formation in adult but not infant B6C3F1 male mice. Environ Mol Mutagen 2001 37 (2) 164 72. 

As mentioned above, pentachlorophenol has different solubility at acid and neutral pH. It was shown that this compound toxicity also depends on pH °. Studies of wastewater from a Baikalsk pulp and paper mill allowed one to evaluate a pure cellulose bleaching process pollution, as Lake Baikal, where it is located, has no agriculture and only little municipal pollution ". Although mutagenic activity was effectively decreased during... 

C. In animal studies, pentachlorophenol is mutagenic, teratogenic, and carcinogenic. DNP is teratogenic and may be weakly carcinogenic. 

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