Muscarinic cholinergic receptor MAChR

Eriksson and co-workers have reported that neonatal exposure to low doses of the pyrethroids bioallethrin and deltamethrin by oral administration from postnatal days 10 to 16 induced an increase in muscarinic cholinergic receptor (MAChR) density in cerebral cortex at the age of 17 days. That resulted in a decrease in the cortical MAChR density, an increase in motor activity, and a lack of habituation at the adult age of 4 months in mice [48-50]. 

Abbreviations AON, anterior olfactory nucleus mAChR, muscarinic cholinergic receptor nAChR, nicotinic cholinergic receptor alpha and beta adrenergic receptors NMDA, N-methyl-D-Aspartate receptor AMPA, a-amino-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GABAa/b, gamma aminobutyric acidreceptor. 

This portion of the cholinergic nervous system can be further subdivided into the muscarinic and nicotinic systems, because the structures that are innervated have receptors for the alkaloids muscarine (mAChR) and nicotine (nAChR), respectively, and can be stimulated by these compounds. Mus-... 

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