Copper-free Sonogashira coupling

A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling, Org. Lett. 4, 10 (2002) 1691-1694. [Pg.124]

Scheme 7.2 Copper-free Sonogashira coupling reaction in supercritical water...

High-pressure and high-temperature conditions are effective for flash chemistry. It has been reported that copper-free Sonogashira coupling... [Pg.167]

In copper-free Sonogashira coupling the competition of ligand and amine base determines the reaction mechanism. The oxidative addition of Arl with (Ph3P)4Pd is faster when amine is present. With the proposed mechanisms the efficiency of PhsP > PhsAs is explained. [Pg.427]

Y. Ikushima, Rapid and highly selective copper-free Sonogashira coupling in high-... [Pg.620]

Liang B, Dai M et al (2005) Copper-free Sonogashira coupling reaction with PdCl in water under aerobic conditions. J Org Chem 70 391-393... [Pg.251]

Soheili, A., Albaneze-WaUcer, J., Murry, J. A., Dormer, P. G., and Hughes, D. L. (2003). Efficient and general protocol for the copper-free Sonogashira coupling of aryl bromides at room temperature. Org. Lett., 5, 4191 194. [Pg.16]

Fukuyama, T., Shinmen, M., Nishitani, S., Sato, M. Ryu, I. (2002). A Copper-Free Sonogashira Coupling Reaction in Ionic Liquids and Its Application to a Microflow System for Efficient Catayst Recycling, Org. lett., 4, p>p. 1691-1694... [Pg.267]

Colacot TJ, Li H, Pu X (2013) Heck alkynylation (copper-free sonogashira coupling) of aryl and heteroaryl chlorides, using Pd complexes of t-Bu2(p-NMe2C6lLi)P understanding the structure-activity relationships and copper effects. J Org Chem 78 568-581... [Pg.573]

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