Multivalent ligand design

Z. Zhang, J. C. Pickens, W. G. J. Hoi, and E. Fan, Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design, Org. Lett., 6 (2004) 1377-1380. 

Synthetic, Multivalent Ligands Designed to Induce L-Selectin Shedding... 

M. Mammen, S.-K. Choi, and G. M. Whitesides, Polyvalent interactions in biological systems Implications for design and use of multivalent ligands and inhibitors, Angew. Chem. Int. Ed. Engl., 37 (1998) 2754—2794. 

Krishnamurthy VM, Estroff LA, Whitesides GM. Multivalency in ligand design. In Jahnke W, Erlanson DA, editors. Fragment-based approaches in drug discovery. Weinheim Wiley 2006. 

A variety of functional polymers has been designed and demonstrated to be a tool of multivalent ligand-immobilized polymers. However, the binding constant using such polymers was not as enhanced as expected. Such unsatisfying results using a functional polymer were mainly attributed to a spatial mismatch between the... 

One of the possible applications directly related to multivalent ligand-receptor interactions will be the design of polymeric inhibitors which specifically bind receptors existing on cellular membranes to inhibit the uptake of biological substrates via the receptors. For example, there are many kinds of intestinal membrane transporters for... 

Polyvalent Interactions in Biological Systems Implications for Design and Use of Multivalent Ligands and Inhibitors. Ange-wandte Chemie International Edition, 2754-2794. 

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