Multiplex spectrometric methods

Mass spectrometric methods have a huge potential to overcome these limitations. While GC-MS has found a fundamental role in toxicology and occupational medicine it did not find a place in the routine clinical chemistry laboratory due to its very demanding handling not suitable for a 24 h/7 day service laboratory setup. The introduction of LC-MS has improved the practicability and robustness of highly specific and highly multiplexed mass spectrometric analyses very substantially. 

As pointed out earlier, these described methods would, in principle, also be applicable to other detection platforms however, the accuracy and speed of mass spectrometric analysis, combined with its multiplexing capabilities, makes the use of mass spectrometers especially attractive for analyzing a large number of samples. 

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