Multiple sclerosis Gilenya

Fingolimod (Gilenya) The First Oral Treatment for Multiple Sclerosis... 

FTY 720 440 is synthesized by a three-multicomponent Petasis reaction involving benzylamine 437, glycerine 438, and boronic acid 439 (Scheme 6.67). The desired product is obtained in 50% yield, which is further hydrogenated to FTY 720 (Gilenya ) 440 (45% yield over 2 steps) [135]. The latter is a clinically investigated immunosuppressive and shows also promising clinical results in the treatment of multiple sclerosis. 

SIP is the sequestration of lymphocytes, thus attenuating the autoimmune response. The development of selective agonists for the SIP receptor has been a topic of great interest in both academia and pharmaceutical industry. For example, fingolimod (Gilenya , 132) is the first orally active dmg for the treatment of multiple sclerosis (Figure 2). 

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