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Gilenya

Fingolimod (Gilenya) The First Oral Treatment for Multiple Sclerosis... [Pg.255]

FTY 720 440 is synthesized by a three-multicomponent Petasis reaction involving benzylamine 437, glycerine 438, and boronic acid 439 (Scheme 6.67). The desired product is obtained in 50% yield, which is further hydrogenated to FTY 720 (Gilenya ) 440 (45% yield over 2 steps) [135]. The latter is a clinically investigated immunosuppressive and shows also promising clinical results in the treatment of multiple sclerosis. [Pg.238]

SIP is the sequestration of lymphocytes, thus attenuating the autoimmune response. The development of selective agonists for the SIP receptor has been a topic of great interest in both academia and pharmaceutical industry. For example, fingolimod (Gilenya , 132) is the first orally active dmg for the treatment of multiple sclerosis (Figure 2). [Pg.32]

See other pages where Gilenya is mentioned: [Pg.257]    [Pg.257]    [Pg.259]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.269]    [Pg.257]    [Pg.257]    [Pg.259]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.269]   
See also in sourсe #XX -- [ Pg.26 ]



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Fingolimod (Gilenya

Multiple sclerosis Gilenya

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