Multiple organic modifiers

The discrepancy of literature data and the urgency of this problem have induced us to study the hemosorption effects of the modified sorbents on the condition of patients with multiple organ failure. 

Bicknell et al. (161) has recently reported the successful transfer onto SP of a modified version of the Tsuge reaction (162) to produce a 96-member discrete hbrary L5 of tricyclic compounds by means of a commercially available automated SP multiple organic synthesizer (163). In this synthetic adaptation, the Tsuge reaction, that is, cycloaddition of pyridinium methilides with olefinic dipolarophiles, as shown in... 

Two other reasons ILs have not attracted wider interest as putative organic modifier replacers are (1) their poorer UV transparency and (2) higher cost. Conversely, the successful use of these ionic compounds in IPC relies on the multiplicity of roles they can play simultaneously. The use of ILs as silanol suppressors (described in Chapter 5) and as IPRs (discussed in Chapter 7) demonstrates that they are versatile reagents in IPC as confirmed by their ability to control retention of ionized sample without including the organic modifier in the eluent. For this reason, they were proposed as environmentally friendly mobile phases [20],... 

For more hydrophobic analytes, the retention can be modulated by the addition of organic modifiers such as methanol in the mobile phase. However, there is not a linear relationship between the amount of the organic modifier in the mobile phase and the retention factor of the enantiomeric analytes, indicating multiple types of retention interactions [75]. 

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