Multiple high resolution mass

Amad, M.H. Houk, R.S. High-Resolution Mass Spectrometry With a Multiple Pass Quadrapole Mass Analyzer. Anal. Chem. 1998, 70,4885-4889. 

Fig. 10 Gas chromatography-electron-capture negative-ion high-resolution mass spectrometry multiple-ion chromatogram (sum of penta-octachlorobornanes) of a sediment sample from the Mississauga Basin of Lake Ontario (2-3 cm depth) showing predominance of B6-923 and B7-1001 [84]. Other congener identities are defined in ref [84]. [Reproduced with permission from SETAC]...

The determination of TCDD in the final extract was by high resolution mass spectrometry multiple scan averaging. No gas chromatography was employed the sample was vaporized via the direct insertion probe (12.13). This method is inherently more prone to interferences than GC-MS (17.18) the response observed may not be due to TCDD. The results do serve as an indication, however, that if TCDD is present in human milk it is at 1 ppt or less. Thus any methods developed must be capable of this detection limit. 

Upjohn scientists isolated a potent inhibitor of the cholesteryl ester transfer protein U-106305. The high-resolution mass spectrum indicated that the formula was C28H41NO, and the spectrum had 27 distinct resonances (including one pair of equivalent carbons at 8 20.02). DEPT spectra indicated the multiplicities given in the following table ... 

In the case of completely unknown compounds, the molecular formula is a useful source of additional information it can be determined using small amounts of substance (a few micrograms) by high-resolution mass spectrometric determination of the accurate molecular mass. It provides information concerning the double-bond equivalents (the degree of unsaturation —the number of multiple bonds and rings). 

M. H. Amad and R. S. Houk, High-resolution mass spectrometry with a multiple pass quadrupole mass analyzer. Anal. Chem. 70, 4885-4889 (1998). 

Blay P, Hui JP, Chang J, Melanson JE (2011) Screening for multiple classes of marine biotoxins by liquid chromatography-high-resolution mass spectrometry. Anal Bioanal Chem 400 577-585. doi 10.1007/s00216-011-4772-2... 

Zachariasova M, Cajka T, Godula M, Malachova A, Veprikova Z, Hajslova J (2010) Analysis of multiple mycotoxins in beer employing (ultra)-high-resolution mass spectrometry. Rapid... 

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