Multimolecular host-guest inclusion

THE DESIGN AND SYNTHESIS OF A FAMILY OF MULTIMOLECULAR HOST-GUEST INCLUSION COMPLEXES... 

Fig. 1 Definitions and overall scheme of supramolecular events (a) chemical host synthesis and formation of a supramolecule (host-guest inclusion compound) (b) endo- and exosupramolecular receptor-substrate (host-guest) chemistry and (c) formation of mono-and multimolecular inclusion compounds.

Fig. 2. Classification/nomenclature of host—guest type inclusion compounds, definitions and relations (/) coordinative interaction, (2) lattice barrier interaction, (J) monomolecular shielding interaction (I) coordination-type inclusion compound (inclusion complex), (II) lattice-type inclusion compound (multimolecular/extramolecular inclusion compound, clathrate), (III) cavitate-type inclusion compound (monomolecular/intramolecular inclusion...

Figure 14 Monomolecular and multimolecular inclusions in host-guest complexes...

In 1979 the bieyclic diol exo-2,ejco-6-dihydroxy-2,6-dimethylbicyclo[3.3.1]nonane (i) was prepared and observed to co-crystallise with various solvents, including ethyl acetate, chloroform, toluene, dioxane, and acetone. A crystal structure determination of the ethyl acetate compound revealed the occurrence of a helical canal host structure, containing ethyl acetate as guest (with 3 1 diol ethyl acetate stoichiometry), and that spontaneous resolution had occurred on crystallisation of the multimolecular inclusion compound 6>. 

This type of structure is an example of an organic multimolecular inclusion complex, dependent on the entire packing arrangement of host molecules providing void spaces which can be occupied by guest molecules. Such materials include th familiar examples of he clathrates formed by Dianin s compound, and by hydroquinone, and the canal complexes formed by urea with n-alkanes. ... 

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