Multidose powders, preparation

The preparation of the powder mixture is analogous to the preparation of single-dose powders (see Sect. 4.5), but the flow properties are less critical, because the powder mixture does not have to be distributed evenly over dose units. A diluent is generally not necessary, but in case it is required, lactose is often used. Bulk or multidose powders can be packaged in glass, plastic, metal or other containers that have a wide mouth to allow the handling of the powdermeasuring device. 

Sodium sulfate is an example of multidose powder, which is used as laxative in case of intoxication the patient should take several grams. To make this preparation more patient-friendly, the required quantity of Sodium sulfate decahydrate can be weighed into a dry bottle, which basically makes it a divided powder. Prior to use, the required amount of water is added to dissolve the powder. This may be drme in the pharmacy or elsewhere by the patient or the caregiver. An advantage of a powder over an oral solution is that the preparation has a l(Mig shelf life without the need for a preservative. 

Mixing of solids takes place in the pharmacy in the preparation of capsules, single-dose powders and multidose powders. But also in the preparation of suppositories and dermal preparations solids may first be mixed together before they are combined with the base. A common reason for this is that mixing solids may give an opportunity to ... 

Parenteral preparations are filled into various types of containers, depending on the nature of the product. Single-dose injections are filled into glass ampoules sealed by fusion or ex tempore into plastic syringes. Multidose injections are delivered in glass vials sealed with rubber closures with mechanical properties suitable for multiple piercing. Concentrates and powders for injections or infusions are also... 

The structure of this chapter is such that after orientation on the application of oral dosage forms and their definitions, at first the general aspects of formulation and preparation of powder mixtures are dealt with. Specific information about the respective dosage forms are then given in separate sections on capsules and powders (single dose, multidose and cachets). 

Oral powders are preparations consisting of solid, loose, dry particles of varying degrees of fineness. They contain one or more active substances, with or without excipients and, if necessary, colouring matter (...) and flavouring substances. They are generally administered in or with water or another suitable liquid. They are presented as single-dose or multidose preparations [6]. 

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See also in sourсe #XX -- [ ]

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