Multidimensional detection

M. Cai eii and A. Mangia, Multidimensional detection methods for sepai ations and their application in food analysis . Trends Anal. Chem. 15 538-550 (1996). 

One often finds that when high resolution separation schemes are utilized, other techniques and disciplines must participate in the scheme of understanding and effectively utilizing the separation with subsequent identification of the resulting zones. A rigorous and often multidimensional detection scheme such as mass spectrometry and/or fluorescence is found both for the life science and industrial polymer applications. Other disciplines including informatics and statistics are often... 

Figure 10.6. Setup for size exclusion chromatography with multidimensional detection.

Careri, M. Mangia, A. Multidimensional detection methods for separations and their apphcation in food analysis. Trends Anal. Chem. 1996,15 (10), 538-550. 

The two-detector system also provides qualitative information about peak purity and sample pJCa. This information is gained by plotting the two detector outputs against each other. In addition to the usual ratio plots, it is suggested that multidimensional detection in any separation system is best served by plotting the raw detector outputs against each other. This type of implementation of single-column and suppressed 1C provides information beyond the sum total of that obtained with either approach alone. 

Gas Chromatography-Mass Spectrometry Analysis of Anesthetics and Metabolites Using Multidimensional Detection Strategies... 

The next five chapters deal with pharmaceutical and clinical applications of GC-MS, paying attention to automated sample pretreatment procedures for rapid GC-MS of drugs (Ch. 9), multidimensional detection strategies in the analysis of anesthetics (Ch. 10), the use of stable isotope-ratio GC-MS in clinical applications (Ch. 11), steroid profiling in relation to a variety of diseases... 

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