Multidetector size-exclusion chromatography

Jackson, C. and Yau, W. W., Computer simulation study of multidetector size-exclusion chromatography. Flory-Schulz molecular weight distribution, in Chromatographic Characterization of Polymers, Hyphenated and Multidimensional Techniques, Provder, T., Barth, H. G., and Urban, M. W., Eds., American Chemical Society, Washington, D.C., 1995, chap. 6. 

Computer Simulation Study of Multidetector Size-Exclusion Chromatography... 

The use of multiple detectors with size-exclusion chromatography (SEC) can greatly increase the information content available from a typical SEC analysis. This multidetector approach permits more accurate measurement of polymer properties than conventional SEC. The additional information, however, is obtained at the expense of an increase in the complexity of the instrumentation and data handling. In particular, a number of concerns arise in data acquisition and processing that are not present in conventional SEC. Some of these difficulties are outlined, and possible solutions are discussed. 

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