Multicomponent Petasis-Borono-Mannich Reaction

Organoboron compounds have gained special attention and importance in the last years due to their use in different processes, but one of the most important and efficient protocols is the multicomponent Petasis-borono-Mannich (PBM) reaction [17-19]. In this approach, an amine, an aldehyde, and a boronic acid react to give access to a new amine 

After the pioneering work reported by Petasis and coworkers in 1993 for the preparation of tertiary allylamines and applied to the synthesis of natifine [17a], the PBM MCR has been intensively explored for the obtainment of several organic molecules bearing distinct functional groups sudi as a-amino acids [20], a-hydroxyl amines [21], 2-hydroxymorpholines [22], alkylaminophenols, and 2/7-chromenes [23,24], 

Although interesting revisions have been published covering this area [18, 24], here, we would like to show some key works developed during the second part of the last decade. 

SCHEME 4.12 Synthesis of rotaxane 20 by multicomponent self-assembly. 

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Candeias NR, Montalbano F, Cal PMSD et al (2010) Boronic Acids and Esters in the Petasis-Borono Mannich Multicomponent Reaction. Chem Rev 110 6169-6193... 

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