Multicomponent Domino Process Rational Design and Serendipity

Multicomponent Domino Process Rational Design and Serendipity 

Contrary to the general perception, MCR occupies an important position in the development of modern organic chemistry. Indeed, many important named reactions such as the Strecker amino nitrile synthesis (1850) [6], the Hantzsch dihydropyridine synthesis (1882) [7], the Biginelli dihydropyrimidine synthesis (1891) [8], the Mannich reaction (1912) [9], the isocyanide-based Passerini reaction (1921) [10], and the Ugi (1959) reaction [11], among others, are all multicomponent processes. In spite of the significant contribution of MCRs to the state of the art of modern organic chemistry and its demonstrated potential in the synthesis of 

Domino Reactions Concepts for Efficient Organic Synthesis, First Edition. Edited by Lutz F. Tietze. 

1) Michael addition could be reversible, depending on the nature of nucleophiles. However, when RM (R = alkyl, alkenyl, M = metals) was used as nucleophiles, the 1,4-addition became essentially irreversible. 

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I 75 Multicomponent Domino Process Rational Design and Serendipity... 

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