MRFIT Multiple Risk Factor

K/DOQI Kidney Dialysis Outcomes and Quality Initiative MAP mean arterial blood pressure MDRD Modification of Diet in Renal Disease MRFIT Multiple Risk Factor Intervention Trial NHANES III Third National Health and Nutritional Examination Survey... 

Brancati FL, Whelton PK, Randall BL, et al. Risk of end-stage renal disease in diabetes mellitus a prospective cohort study of men screened for MRFIT. Multiple Risk Factor Intervention Trial. JAMA 1997 278 2069-2074. 

Grimm RH Jr, Cohen JD, Smith WM, Falvo-Gerard L, Neaton JD. Hypertension management in the Multiple Risk Factor Intervention Trial (MRFIT). Six-year intervention results for men in special intervention and usual care groups. Arch Intern Med 1985 145(7) 1191-9. 

Figure 26-22 Relationship between cholesterol concentration and coronary heart disease mortality expressed by yearly rate per 1000 and risk ratios (Multiple Risk Factor Intervention Trial [MRFIT] participants). (From Grundy SA1. Cholesterol and coronary heart disease A new era. JAMA i 986,256 2849-55. Copyright 1986, American Medical Association.)...

On the basis of findings from studies such as the MRFIT and the LRC-CPPT discussed previously, hypercholesterolemia in adults is now defined in terms of CHD risk. The National Institutes of Health ATP of the NCEP has issued its third report for the detection, evaluation, and treatment of hypercholesterolemia (ATP III). The ATP III built on earlier reports and expanded the indications for intensive cholesterol lowering. In ATP I, strategies for primary prevention of CHD in subjects with LDL-C >160mg/dL or 130 to 159mg/dL and multiple risk factors... 

Kuller L H, Tracy RP, et al. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. Am J Epidemiol 1996 44 537-47. 

Prineas RJ, Grandits G, Rautaharju PM et al. Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT]). Am J Cardiol 2002 90 1391. 

The initial step in management is to modify the major risk factors for HID—hypertension, hypercholesterolemia, and smoking— and data from the Multiple Risk Factor Intervention Trial (MRFIT) show these interventions to be useful in patients with silent ischemia. In a subset of the study population that had abnormal baseline exercise ECG responses, the special intervention group had a 57% reduction in coronary heart disease death (22.2 of 1000 versus 51.8 of 1000) and a reduction in sudden death resulting from cessation of smoking and lowering of blood pressure and cholesterol when compared with the usual-care group. 

Stamler, J. A. Caggiula G.A. Grandits M. Kjelsberg J.A. Cutler. Relationship to blood pressure of combinations of dietary macronutrients findings of the multiple risk factor intervention trial (MRFIT). Circulation 1996, 94, 2417-2423. 

MRFIT indicates Multiple Risk Factor Intervention Trial. 

Stamler J, Caggiula AW, Cutler JA et al. (1997) Dietary and nutritional methods and findings The Multiple Risk Factor Intervention Trial (MRFIT). American Journal of Clinical Nutrition 65(1 supplement) 183S 02S. 

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