MPEG-PCL

MPEG-PCL Methoxy poly(ethylene glycol)-poly(e-caprolactone)... 

Liao, H.T., Chen, Y.Y., Lai, Y.T., Hsieh, M.F., Jiang, C.P., 2014. The osteogenesis of bone marrow stem cells on mPEG-PCL-mPEG/hydroxyapatite composite scaffold via soUd freeform fabrication. Biomed Research International 2014, 321549. 

T. Wang, X.-J. Jiang, Q.-Z. Tang, X.-Y. Li, T. Lin, D.-Q. Wu, et al.. Bone marrow stem cells implantation with alpha-cyclodextrin/MPEG-PCL-MPEG hydrogel improves cardiac function after myocardial infarction, Acta Biomater. 5 (2009) 2939—2944, http // dx.doi.org/10.1016/j.actbio.2009.04.040. 

M.S. Kim, K.S. Seo, H. Hyun, G. Khang, S.H. Cho, H.B. Lee, Controlled release of bovine serum albumin using MPEG-PCL diblock copolymers cis implantable protein carriers. Journal of Applied Polymer Science, 102,1561-7,2006. 

Scheme 12.5 Synthesis of MPEG-PCL by ring opening polymerization.

Amphiphilic and cationic triblock copolymers consisting of MPEG, PCL, and poly-12 (R=CH2CH2NH2) were also obtained. Cyclic phosphates (12) (R=Me, Et, Pd) were used to adjust the hydrophobic-hydrophilic balance of the copolymers and influence their thermosensitivity in a wide range. 

However, unlike the block copolymer of thermoresponsive PPE with PGL or PEG, the ABC 3-miktoarm star terpolymer (MPEG)(PCL) (PPE) (9) self-assembles into nanopartides in aqueous solution but changes its morphology with temperature variation. The terpolymer (MPEG)(PCL) (PPE) is... 

To make amino-group functionalized PPEs, which will be positively charged and therefore have potential for nucleic add delivery, the functional phosphoester monomer 2-(N-tert-butoxycarbonyla-mino)ethoxy-2-oxo-l,3,2-dioxaphospholane (PEEABoc) (17) has been synthesized. Based on the ROP of PEEABoc using hydroxyl-terminated MPEG-b-PGL as the macroinitiator, an amphiphilic and cationic triblock copolymer consisting of MPEG, PCL, and poly(2-aminoethyl ethylene phosphate) has been developed, which is denoted mPEG-b-PCL-f -PPE-EA (eqn [10]). This amphiphilic polymer can self-assemble into nanopartides in aqueous solution and absorb siRNA for RNAi-based therapy. 

MTX MCC mPEG MA NFX PEO PCS PECs PLA PBLA PLG PPO PEG PCL PBLG PBS PGA Methotrexate Crystalline cellulose Monomethoxypoly(ethylene glycol) Maleic acid Norfloxacin Polyethylene oxide) Photon correlation spectroscopy Poly(electrolyte complexes) Poly(L-lactic acid) Poly( 3-benzyl-L-aspartate) Poly (lactide- co -glycolide) Polypropylene oxide) Polyethylene glycol) Poly(e-caprolactone) Poly(y-benzyl-L-glutamate) Phosphate buffered saline Poly(glycolic acid)... 

Lu Y, Liu L et al (2007) Novel amphiphilic ternary polysaccharide derivates chitosan-g-PCL-b-MPEG synthesis, characterization, and aggregation in aqueous solution. Biopolymers 86 403 08... 

As a result, random and/or block copolymers were obtained. Aluminum alkoxides and/or Sn(Oct)2 were usually applied as initiators. In some cases, polymerization of cyclic phosphates was initiated by hydroxy-terminated compounds dodecanol, MPEG, poly-L-lactide (PLLA), and poly(8-caprolactone) (PCL) with Sn(Oct)2 as the catalyst. 

Polymerization of structure 12 (R=MPEG 750) on PCL block gave brush-coil diblock copolymer containing 62 monomer units of CL and up to 6 PEG brushes per polymer chain. 

The synthesis of four-armed biodegradable star block copolymers of PCL and poly-11 using hydroxyl-terminated four-arm star PCL and a Sn(Oct)2 co-initiation system was also reported. Amphiphilic three ABC-miktoarm star ter-polymers composed of PCL, MPEG, and poly-11 were synthesized by a combination of ROP and click chemistry. 

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