Moxidectin confirmation

Coupling of liquid chromatography with mass spectrometry can provide unequivocal on-line spectrometric identification of anthelminthic residues in animal-derived foods. Typical applications of such techniques include the confirmation of moxidectin residues in cattle fat by liquid chromatography-thermospray mass spectrometry (352), and the confirmation of eprinomectin residues in bovine liver tissue by liquid chromatography, electrospray ionization, and multiple reaction monitoring in the MS-MS mode with positive ion detection (370). 

Liquid chromatography-thermospray-mass spectrometry has been successfully applied for the detection/ confirmation of nicarbazin residues in chicken tissues using negative-ion detection in SIM mode. Liquid chromatography-thermospray-mass spectrometry in SIM mode has also been used for the quantification of residues of moxidectin in cattle tissues and fat, ° and nitroxynil, rafoxanide, and levamisole in muscle. Confirmatory methods based on LC-TSP-MS have been further reported for the determination of penicillin G, cephapirin, and various penicillin derivatives " in mUk. Comparative evaluation of the confirmatory efficiency of LC-TSP-MS and LC-TSP-MS-MS in the assay of maduramycin in chicken fat showed the former approach to be marginally appropriate, whereas the latter is highly efficient. Tandem LC-MS-MS has also been successfully applied in the analysis of residues of chloramphenicol in milk and fish. ... 

Khunachak, A. Dakunha, A.R. Stout, S.J. Liquid-chromatographic determination of moxidectin residues in cattle tissues and confirmation in cattle fat by Uquid-chromatography mass-spectrometry. J. AOAC Int. 1993, 76, 1230-1235. 

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