Mouth nifedipine

Nifedipine is associated with fewer side effects than magnesium or ft-agonist therapy. Five to 10 mg nifedipine may be administered sublingually every 15 to 20 minutes for three doses. Once stabilized, 10 to 20 mg may be administered by mouth every 4 to 6 hours for preterm contractions. 

The sublingual surface area is relatively small but has a rich blood supply. The major advantage of this route is avoidance of intestinal destruction and hepatic first pass metabolism. However, absorption can be highly variable critical factors are the residence time of the drug in the mouth and saliva flow. Premature swallowing or excessive saliva production preclude efficient absorption. Nitroglycerin, nifedipine, propranolol, and buprenorphine are all available as sublingual preparations. Rectal... 

For immediate pre-exertional prophylaxis glyceryl trinitrate sublingually or nifedipine (bite the capsule and hold the liquid in the mouth or swallow it). 

Dijfuse oesophageal spasm may be helped by isosorbide dinitrate 5 mg sublingually or 10 mg by mouth, or by nifedipine 10 mg sublingually or swallowed. 

A 70-year-old man with hypertension took nifedipine 10 mg bd and 3 months later developed a pruritic eruption on his back, which spread to cover his trunk, limbs, face, and scalp, with involvement of the mouth. His skin deteriorated after the dosage of nifedipine was increased to 20 mg bd 1 year later. Antibodies to the 230 kDa pemphigoid antigen were detected in his serum. His skin improved considerably after withdrawal of nifedipine and the use of topical steroids and oral minocycline. 

Mouth Gingival enlargement is often associated with calcium channel blockers and ciclosporin. In 93 renal transplant recipients who had taken ciclosporin ( = 31), ciclosporin -b nifedipine ( = 31), or ciclosporin -b amlodipine (n = 31), more... 

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