Mouse zinc deficiency

Esophagus (mouse model of BE) DOC (as dietary supplement also zinc deficiency) 9... 

DePasquale-JarHTeu, P., and Fraker, P. J. (1979). The role of corticosterone in the loss in immune function in the zinc-deficient A/J mouse. J. Nutr. 109 1847-1855. 

EFFECT OF DIETARY ZINC DEFICIENCY ON LYMPHOCYTE FUNCTION IN THE MOUSE... 

The frequency of zinc deficiency in the United States as well as other countries raised legitimate questions about the effects of zinc deficiency on health and immunity. The possibility that large numbers of malnourished or protein-caloric deficient children may also be zinc deficient increased the concern. To this end we set out to determine the effects of dietary zinc deficiency on lymphocyte function at the various stages of development beginning with the young adult mouse. Results collected in the last two years will be reviewed herein. 

Leucke et al. (1968) had observed that the most atrophied organ in the zinc deficient pig was the th3mius. After only 28 days on a zinc deficient diet we found that the thymus of the A/J mouse had also undergone rapid thymic atrophy (Table I),... 

As in the young adult mouse, dietary zinc deficiency appeared to have a more pronounced effect on helper T-cells than B-cells, Upon nutritional repletion, full immune competency was manifest in the neonatally-treated mice in less than seven days (Zwickl and Fraker, in press). 

Huang L, Gitschier J (1997) A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet 17 292-297... 

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