Mouse kidney animal models

The parathyroid glands in FHH are reset to maintain a higher than normal serum calcium concentration owing to impaired suppression of PTH release in the face of hypercalcemia (e.g., resistance to CaQ+) (Fig. 2). Similarly the kidneys show a reduced calciuric response to hypercalcemia, which contributes to the hypercalcemia by promoting inappropriately reabsorption of calcium. Mouse models of FHH and NSHPT result from targeted inactivation of one or both CaR alleles, respectively [1,3]. These animals have provided valuable insights into the alterations in tissue function resulting from loss of the receptor. 

Fig. 4. In vivo bioluminescent monitoring of the progression of P. mirabilis Xen 44 in the mouse model of catheter-induced urinary track infection (UTI). The ascending nature of uropathogen from the bladder up the ureters and to the kidney can be clearly visualized from outside intact live animals using luciferase tag pathogen and bioluminescence imaging. (See Color Plate 8, following p. 46.)...

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