Mouse cancer risk assessment

An additional variable not dealt with completely in these risk analyses, is the expected type of tuoior. The tumors produced in the mouse were hemangioendotheliomas in the abdominal organs and tissues. Aniline residues passing through the human bladder are suspect as having the potential of producing more serious tumors at this site. This variable adds to the uncertainty of cancer risk assessment for human exposure based on laboratory animal data. 

Risk Assessment. This model successfully described the disposition of chloroform in rats, mice and humans following various exposure scenarios and developed dose surrogates more closely related to toxicity response. With regard to target tissue dosimetry, the Corley model predicts the relative order of susceptibility to chloroform toxicity consequent to binding to macromolecules (MMB) to be mouse > rat > human. Linking the pharmacokinetic parameters of this model to the pharmacodynamic cancer model of Reitz et al. (1990) provides a biologically based risk assessment model for chloroform. 

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