Motility inhibitory factor

Motility Inhibitory and Zoospore Lytic Factors from Unripe Ginkgo Fruits... 

Taurine (2-aminoethanesulfonic acid 4.235) is an inhibitory neurochemical that probably acts primarily as a neuromodulator rather than a neurotransmitter. It is formed from cysteine, and its accumulation can be prevented by the cardiac glycoside ouabain. Although receptor sites and specific actions cannot be elucidated without an antagonist, taurine has been implicated in epilepsy and, potentially, in heart disease. There are a large number of physiological effects attributed to taurine, among them cardiovascular (antiarrythmic), central (anticonvulsant, excitability modulation), muscle (membrane stabilizer), and reproductive (sperm motility factor) activity. Analogs of taurine, phthalimino-taurinamide (4.236) and its iV-alkyl derivatives, are less polar than taurine and are potent anticonvulsant molecules. 

Harmine proved to be a potent angiogenic inhibitor, which was extensively evaluated by in vitro and in vivo experiments, in vitro, it was able to reduce different steps of neo-vessel formation by VEGF-induced HUVEC, including proliferation, motility, invasion, and tube formation. Additionally, harmine showed inhibitory effect on transcription factors related to crucial tumor development and angiogenesis process. It reduced the translocation and activation of... 

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