Most probable route coordinate

Scheme 3 depicts the likely reaction path, involving a transition state like 4. The reaction of mercury(II) acetate with [Pt(2-Me2NCH2C6H4)2] is related, and produces compounds with mercury-platinum bonds. Equation (6) shows the most probable route, this time leading to a six-coordinate product. There is evidence (electrochemical and uv/visible... 

The major product of the reaction obviously arises from attack of a cis coordinated amido ion on the P center of the phosphate ester since there is no other source of nitrogen in the reaction, the minor product, however, the [(NH3)5lrEP]+ ion could come from a variety of sources. The most obvious route is by intermolecular attack of hydroxide ion on the coordinated ester. Such is probably not the case, however. The yield of the product is constant over the range of hydroxide ion concentrations studied where the contribution of the overall third-order reaction accounts for 10... 

A highly toxic substance by ingestion, and possibly by most other routes of exposure moderately toxic by inhalation and skin contact cholinesterase inhibitor toxic effects are similar to those of other carbamate pesticides and include excessive salivation, lacrimation, slow heart rate, blurred vision, twitching of muscle and lack of coordination, nausea, weakness, diarrhea and abdominal pain oral intake of probably 1.5-3 g could be fatal to adult humans a teratogenic substance, producing adverse reproductive effects in experimental animals. 

Activation of propargylic alcohols containing a G-H bond in / -position with respect to the OH group by a coordinatively unsaturated complex is probably the most general route for the preparation of alkenyl-vinylidene derivatives [M]=G=GHGR =GR R (Scheme 24). This process proceeds through the initial formation of an unstable hydroxy-vinylidene intermediate, which undergoes a spontaneous dehydration. In some cases, stable... 

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