Morphology Gradient

Figure 7.4.3 DCCA ordination diagram for the hydromorphological gradient analysis, with the morphological gradient indicated by black (canalised), grey (semi-natural) and open (natural) labels and with the hydrological periods indicated by circles (pre-hydrological restoration) and triangles (post-hydrological restoration)...

S. Morgenthaler, C. Zink, N.D. Spencer, Surface-Chemical and -Morphological Gradients. Soft Matter (2008) Vol. 4 pp. 419-434. 

T.P. Kunzler, T. Drobek, M. Schuler, N.D. Spencer. Systematic Study of Osteoblast and Fibroblast Response to Roughness by Means of Surface Morphology Gradients. Biomaterials (2007) Vol. 28 pp. 2175-2182. 

A variety of morphological gradients with identical topography and different surface chemistry was prepared, following the procedure summarized in Figure 1. 

Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients... 

Kunzler TP, Drobek T, Sprecher CM, Schuler M, Spencer ND. Fabrication of material-independent morphology gradients for high-throughput appHcations. Appl Surf Sci 2006 253 2148-53. 

Huwiler C, Kunzler TP, Textor M, Voros J, Spencer ND. Functionalizable nano-morphology gradients via colloidal self-assembly. Langmuir 2007 23 5929-35. 

Fabrication of material-independent morphology gradients for high-throughput apphcations... 

We have presented a simple method for the production of morphology gradients, which have the potential to facilitate high-throughput studies. A gradient was produced using the combination of particle erosion with a subsequent chemical... 

We will first discuss the preparation methods that have been proposed in the literature and then cover the applications that have been addressed with surface gradients. The following section will be divided into the preparation of chemical gradients and the preparation of morphological gradients. 

Within the last decade, various approaches have been described to fabricate different kinds of morphological gradients, varying in feature shape and size, length and in the fundamental principle that is used to create them. In order to compare these techniques, those fabricated by similar basic principles have been grouped together. 

Chemical and morphological gradients have been used in a variety of applications, especially in the biomedical held and... 

The adhesion of cells is important in many biomedical applications, for example for hip or dental root implants. A successful integration of these implants requires that bone cells adhere to the implant surface and proliferate. It is therefore important to understand the adhesion and proliferation of cells on surfaces with different properties, e.g. wettability or roughness. Different types of graxlients, wettability, polymer-chain density, protein and morphology gradients, have therefore been used to study cell adhesion. 

Surface chemical and morphological gradients have also been used for several other purposes, ranging from the study of fundamental phenomena to industrial applications. 

Fabrication of Material-Independent Morphology Gradients for High-Throughput Applications... 

Functionalizable Nano-Morphology Gradients via Colloidal Self-Assembly Christoph Huwiler, Tobias Kiinzler, Marcus Textor, Janos Voros,... 

Surface-Chemical and -Morphological Gradients (Review Article) Sara Morgenthaler, Christian Zink, Nicholas D. Spencer Soft Matter, 2008 4 pp 419-434... 

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