Morpholine-type fungicides

The N-cycloaliphatic derivatives of tetrahydro-l,4-oxazine (morpholine) or those with a long-chain alkyl groups are good specific fungicides against powdery mildew fungi (cereals, cucumbers, apples, roses, etc.) (Pommer and Kradel, 1967). 

Roots and leaves of the plants both take up these active substances. They are distributed in the plants by translocation from the root, and protect the plants for 

3-4 weeks against infection by phytopathogenic fungi. Morpholine-type fungicides also have an eradicant action when applied on the leaves. 

Morpholine (40) can be obtained in a satisfactory yield by the cyclisation ofbis-(2-hydroxyethyl)amine (41) with the elimination of water  

Cyclisation can be performed more simply and with a better yield if the amine-hydrogen is substituted for an alkyl radical (R) and the OH groups are located at a secondary carbon atom (43)  

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