Morphine sulfate controlled-release formulations

Controlled-release oral formulation of morphine sulfate is indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. These formulations are not intended for use as a PRN analgesic. 

Surgical acute pain the only indication for postoperative use of the controlled-release oral formulation of morphine sulfate is if the patient is already receiving the drug prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. 

Chronic non-malignancy pain controlled-release oral formulation of morphine sulfate could be administered in a more convenient schedule than immediate-release oral morphine products, and significantly improves pain control at a lower daily opioid dose, with less rescue doses for breakthrough pain. 

Cancer pain controlled-release oral formulation of morphine sulfate is a well-recognized oral agent for the treatment of cancer pain. 

Ease of use, tolerability controlled-release oral formulations of morphine sulfate provide significant pain relief, ensure uniform blood concentrations, offer less frequent dosing, fewer adverse side effects, and flexible titration with different dosing strengths. 

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