Morphine salts

Once optical resolution is achieved, measurements of the ease of racemization can provide a qualitative picture of the severity of the molecular distortion. Bell and Waring (1949), who coined the phrase molecular overcrowding , were able to detect mutarotation in solutions of the morphine salt of 3,4,-5,6-dibenzophenanthrene-9,10-dicarboxylic... 

Carboxylic and other acids A suitable base, e.g. (—) Brucine (—) Strychnine (—) Morphine Salts Treatment with a suitable acid, e.g. HC1... 

Khan, M.Z.I. Recent trends and progress in sustained or controlled oral delivery of some water soluble drugs morphine salts, diltiazem and captopril. Drug Dev. Ind. Pharm. 1995, 21 (9), 1037-1070. 

Dumortier G, Zuber M, Ghast F, et al. Systemic absorption of morphine after ocular administration evaluation of morphine salt insert in vitro and in vivo. Int J Pharm 1990 59 1-7. 

A neutral solution of a morphine salt gives a blue color with neutral solution of ferric chloride. 

Spirit of Ethyl Nitrite. Spirit of nitrous ether sweet spirit of niter. An alcoholic soln of ethyl nitrite, contg 3.5 -4.5% ethyl nitrite. Incompat Antipyrine, tannin, acetanilide. acetophenetidin, iodides, tincture guaiac. morphine salts, carbonates, acacia. 

I. Salt or Base. Salt or Base. Morphine. Salt or Base. Morphine... 

Examples of oxidation reactions in oral liquids can be found at ferrous salts, morphine salts and phenothiazine derivatives. 

Morphine salts are converted to the inactive pseudomorphine at pH > 4.5 in the presence of oxygen. Therefore in the example formulation of Table 5.23 the solution is acidified with citric acid to pH 2.5-3.5. Disodium edetate is added for further protection against oxidation. 

Absolute patients with known hypersensitivity to morphine, morphine salts, or any components of the product... 

Both morphine free base and its hydrated form are sparingly soluble in water, where only 1 gram of the hydrate will dissolve in 5 litres of water. For this reason, pharmaceutical companies prcxluce sulphate and hydrochloride salts of the thug, both of which are over 300 times more water-soluble than the parent molecule. Since they are derived from a strong acid and weak base, in solution they are at about pH 5 as a consequence, morphine salts are mixed with small amounts of NaOH to make them suitable for injection. 

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