Moracizine

CjH N 57 -54-/) see Etodolac ethyl 3-anilinocarbanilate (C15H16N2O2 37711-28-7) see Moracizine ethyl anthranilate... 

Common Name Moracizine hydrochloride Moricizine hydrochloride... 

MORACIZINE BRONCHODILATORS -THEOPHYLLINE 1 plasma concentrations of theophylline and risk of therapeutic failure Due to induction of microsomal enzyme activity May need to t dose of theophylline by 25%... 

MORACIZINE CALCIUM CHANNEL BLOCKERS Co-administration is associated with t bioavailability of moracizine and 1 availability of diltiazem Postulated that diltiazem inhibits metabolism of moracizine, while moracizine t metabolism of diltiazem the precise mechanism of interaction is uncertain at present Monitor PR, BP and ECG adjust doses of each drug accordingly... 

MORACIZINE CARDIAC GLYCOSIDES -DIGOXIN Case reports of heart block when moracizine is co-administered with digoxin Uncertain at present Monitor PR and ECG closely... 

Digoxin does not interact with a variety of antidysrhjdhmic drugs, including ajmaline, aprindine, lidocaine, lidoflazine (225), and moracizine (226). Other drugs that may have minor and clinically unimportant interactions include cap-topril, carvedilol, disopyramide, and flosequinan. 

Moracizine (moricizine) has Class I antidysrhythmic actions that cannot be easily further subclassified. Its pharmacology, clinical pharmacology, clinical uses, adverse effects and interactions have been reviewed (1-3). 

The overall risk of dysrhythmias with moracizine seems to be similar to that of other antidysrhjdhmic drugs, at around 10% (5), although lower rates have been reported. In CAST-II (the Cardiac Arrhythmia Suppression Trial) moracizine increased mortality in patients with asymptomatic ventricular dysrhythmias after myocardial infarction (6). 

Moracizine has little or no effect on hemodynamics, but it sometimes has adverse hemodynamic effects and can exacerbate heart failure (SEDA-17, 225). 

Moracizine has an anti-aggregatory effect on platelets, and thrombocytopenia has been reported (7). 

Moracizine can cause increased serum bUirubin concentrations and serum transaminase activities (7). 

Moracizine is cleared by the liver, and dosages should be reduced in liver disease (8). 

Cimetidine inhibits the metabolism of moracizine, but the effect is probably clinically unimportant (9). 

Moracizine is an enzyme inducer it increases the rate of clearance of diltiazem (10). Conversely, diltiazem caused a doubling of the AUC of moracizine (10) in healthy volunteers. 

Moracizine is an enzyme inducer it increases the rate of clearance of theophylline (12). 

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