Monosporium bonorden

Characterisation of the antibiotic monordene (also referred to as radicicol) with the elemental composition Cig/Zz/OgCl isolated from Monosporium bonorden gave the macrolide structure 1. The relative configuration of the H atoms on the two conjugated double bonds (6,7-cis, %,9-trans-) could be deduced from the 60 MHz H NMR spectrum The relative configuration of the C atoms 2-5, which encompass the oxirane ring as a partial structure, has yet to be established. 

The antitumor antibiotic radicicol (17) was isolated from Monosporium bonorden and Nectria radicicolaJ Radicicol has been shown to bind to the same amino terminal residue as geldanamycin and similarly block the... 

The resorcylic acid lactone (RAL) radicicol 10 (also known as monorden), was first isolated in 1953 from Monosporium bonorden, and it is the most potent in vitro natural product Hsp90 inhibitor found to date (IC50 = 20-23 nM). However, it is inactive in vivo, due to its metabolically sensitive functionalities (epoxide, Michael acceptor and macrolactone) (Figure 2.7). ... 

Compounds structurally related to zearalenone but of dissimilar biological activity have been isolated from different fungi. Radicicol (29), an antibiotic, was first isolated from Monosporium bonorden. The structure was independently elucidated by McCapra et al. (1964) and Mirrington et al. (1964). 

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