Monosaccharides, imprinting

Figure 17.4 (a) Preparation of the boronic acid complex, (b) Preparation of the monosaccharide imprinted polyphenol, (c) The competitive assay for the detection of D-glucose using the D-glucose-lmprinted polymer. Reproduced with permission from [46]. 

As it has been shown, basically all chiral MIP-based electrochemical sensors were developed up till now for amino acids or monosaccharides. However, chiral pharmaceuticals present more complex structures compared to the already mentioned molecules thus, their efficient molecular imprint is considered to be more difficult. Moreover, in the case of amino acids, the asymmetric carbon is at the molecule s extremity carrying two functional groups (-NH2 and -COOH) strongly interacting with the used common functional monomers, thus easily leading to highly enantiospecific imprinted cavities. 

Granot, E., Tel-Vered, R., Lioubashevski, 0., and Willner, I. (2008). Stereoselective and enantioselective electrochemical sensing of monosaccharides using imprinted boronic acid-fiinctionalized polyphenol films, Adv. Fund. Mater.. 18(3), 478-484. 

Sallacan, N. Zayats, M. Bourenko, T. Kharitonov, A.B. Willner, I. Imprinting of nucleotide and monosaccharide recognition sites in acrylamidephenylboronic acid-acrylamide copolymer membranes associated with electronic transducers. Anal. Chem. 2002, 74 (3), 702-712. 

Nickel, A.M.L. Seker, F. Ziemer, B.P. Ellis, A.B. Imprinted poly (acrylic acid) films on cadmium selenide. A composite sensor structure that couples selective amine binding with semiconductor substrate photoluminescence. Chem. Mater. 2001, 13, 1391-1397. Sallacan, N. Zayats, M. Bourenko, T. Kharitonov, A.B. Willner, I. Imprinting of nucleotide and monosaccharide recognition sites in acrylamidephenylboronic acid-acrylamide copolymer membranes associated with electronic transducers. Anal. Chem. 2002, 74, 702 712. 

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