Enantioselective Electrochemical Sensing

The possibility of chiral electrocatalytic sensing is one of the interesting analytical applications of the studied materials. In the past decade, a variety of chiral materials with electrochemical activity has been reported (Scholz et al., 2002), including tris-chelated complexes adsorbed by montmorillonite (Yamagishi and Aramata, 1984), chiral CuO films deposited onto single-crystal Au (Khotari et al., 2004), and epitaxial electrodeposition of ZnO on Au(IH) (Limmer et al., 2006). 

FIGURE 9.13 Deconvolution of SQWVs for paraffin-impregnated graphite electrodes modified with (a) t-Vg iciZr.Q, 9,9,02 and (b) m-Vg. loZi o, 90O2 immersed into 0.10 M NaOH. Potential scan initiated at -0.15 V vs. AgCl/Ag in the positive direction. Potential step increment. 4 mV square-wave amplitude, 25 mV frequency, 2 Hz. (Adapted from Domenech and Alarcon, 2007, Anal. Chem. 79, 6742-6751, with permission.) 

FIGURE 9.15 Schematics for the electrochemical oxidation of cyclic glucose forms. (From Domenech and Alarcon, 2007. Anal. Chem. 79, 6742-6751, with permission.) 

Controlled potential electrolysis data suggest that under our experimental conditions, the two-electron product of glucose oxidation is almost exclusively formed at -1-0.92 V, whereas for the process at -1-1.15 V, coulometric experiments indicated the consumption of more than two electrons per mole of glucose. 

---

Prasad, B., Srivastava, A., and Tiwari, M. P. (2013). Molecularly imprinted polymer-matrix nanocomposite for enantioselective electrochemical sensing of D- and L-aspartic acid,... 

Granot, E., Tel-Vered, R., Lioubashevski, 0., and Willner, I. (2008). Stereoselective and enantioselective electrochemical sensing of monosaccharides using imprinted boronic acid-fiinctionalized polyphenol films, Adv. Fund. Mater.. 18(3), 478-484. 

---