Monoprotic acids and bases

An additional (electrostatic) shift occurs if the lipid vesicles or micelles have a charged surface, according to the expression suitable for monoprotic acids and bases... [Pg.86]

Equations have been published [16] which relate pKa and p0Ka values to partition coefficient (P) values for monoprotic acids and bases, and diprotic acids, bases and ampholytes. For example, P1 for a monoprotic acid is calculated from... [Pg.27]

The principles developed for titrations of monoprotic acids and bases are readily extended to titrations of polyprotic acids and bases. We will examine two cases. [Pg.206]

The ionization of monoprotic acids and bases and hence their solubility and absorption is dependent on their pK, the pH at which the drug is 50% ionized. First developed by Hammett and published in 1940, the relation between the dissociation constants of benzoic acid derivatives and the longer range electronic (inductive, mesomeric and field) effects is linear and additive. [Pg.340]

To correct capacity factors for ionization, the same equations are used as for the corresponding correction of the apparent partition coefficients. Thus for monoprotic acids and bases, Eqs. 13 and 14 are suggested for extrapolated, as well as isocratic, capacity factors derived froiUg HPLC and RP-TLC I... [Pg.194]

Monoprotic Acids and Bases 18-10 Salts of Weak Bases and Weak... [Pg.753]

Use ionization constants for weak monoprotic acids and bases... [Pg.753]

Ionization Constants for Weak Monoprotic Acids and Bases... [Pg.761]

IONIZATION CONSTANTS FOR WEAK MONOPROTIC ACIDS AND BASES... [Pg.761]

For the single, monoprotic acids and bases in the above example, the distribution and logarithmic concentration diagrams are rather simple, yet they clearly show the relative and absolute concentrations respectively of the various species present. Such diagrams become all the more useful when we consider more complicated systems, such as polyprotic acids and bases, where it otherwise becomes increasingly difficult to envision what happens as a function of pH. We will do so in exercises 4.5 and 4.6. [Pg.126]

So far we have only considered monoprotic acids and bases. Fortunately, the corresponding relations for diprotic and polyprotic acids and bases are quite similar. The relations for diprotic acids and bases will be given here, while those for their polyprotic counterparts (with three or more dissociable protons) can be found in section 4.9. [Pg.148]

Monoprotic acids and bases (with activity correction) pKa = pH - log [Peff / (fiep - Peff)I + [0.509z2l / (1 + O-SlSal / )]... [Pg.627]

The interaction of aqueous solutions of monoprotic acids and bases 15... [Pg.15]

FIGURE 2.3 Interaction of aqueous solutions of monoprotic acids and bases, (a) Titration of a weak acid with a strong base. [Pg.16]

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